eagle-i University of Puerto Rico - Medical Sciences CampusUniversity of Puerto Rico - Medical Sciences Campus
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Laboratory of Fear Learning

eagle-i ID

http://upr.eagle-i.net/i/0000012b-00be-66cd-9e37-5ded80000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    "Our lab studies the mechanisms of emotional regulation using extinction of conditioned fear. Much of what is known about extinction comes from animal models using Pavlovian fear conditioning. We found that a subregion of the prefrontal cortex, the infralimbic cortex (IL), is necessary for extinction (fear inhibition). Moreover, we found that another mPFC subregion, the prelimbic cortex (PL), is necessary for fear expression. We suggest that IL inhibits fear by inhibiting amygdala output, whereas PL drives fear by increasing amygdala output. In addition to our rat studies, we are now studying fear in humans, with the goal of developing new treatments for anxiety disorders."
  2. Contact
    Sotres, Francisco
  3. PI
    Quirk, Gregory, Ph.D.
  4. Website(s)
    http://www.md.rcm.upr.edu/quirk/Home.html
 
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