Roche-Lima, Abiel Laboratory

People:

• PI: Abiel Roche-Lima
  

Resources:

Software

• Chimera ( Algorithmic software component )
  

  Is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311). We use this software for services related to structure model interpretation, visualization and structure prediction.

• Limma – R BioConductor ( Algorithmic software component )
  

  (https://bioconductor.org/packages/release/bioc/html/limma.html) allows processing of linear models and differential expression for microarray data. We use for the statistical analysis and visualization of services with microarray data.

• RFMix ( Algorithmic software component )
  

  Is a powerful discriminative modeling approach that is faster (~30×) and more accurate than existing methods. RFMix is capable of learning from the admixed samples themselves to boost performance and autocorrect phasing errors. RFMix shows high sensitivity and specificity in simulated Hispanics/Latinos and African Americans and admixed Europeans, Africans, and Asians. The software is utilized for ancestry inference services.